褐藻醣膠的好處與臨床功效已經眾多文獻證實：
- 癌症吃褐藻糖膠真的有效嗎？褐藻醣膠的抗癌功效
- 臨床證實！褐藻醣膠活化幹細胞、免疫治療抗癌症
- 抗生素副作用多！褐藻醣膠保護益生菌、防胃潰瘍
- 褐藻醣膠功效多：治退化性關節炎、異位性皮膚炎
- 褐藻糖膠可預防心血管疾病！高血壓高血脂都有效
本文根據褐藻醣膠各方面的保健功能，進行文獻統整：
保健功能1 褐藻醣膠的抗癌潛力
廣告贊助☒
褐藻醣膠的治療應用
Fitton JH, Stringer DN, Karpiniec SS. Therapies from Fucoidan: An Update. Mar Drugs. 2015 Sep 16;13(9):5920-46.[文獻連結]
海洋中的抗癌劑—褐藻醣膠的臨床發現
Kwak JY. Fucoidan as a marine anticancer agent in preclinical development. Mar Drugs. 2014 Jan 28;12(2):851-70.[文獻連結]
海藻衍生的褐藻醣膠能成為未來的抗癌藥物嗎？
Ray M. Lowenthal, J. Helen Fitton. Are seaweed-derived fucoidans possible future anti-cancer agents? Journal of Applied Phycology. 2015 Oct;27(5):2075–2077.[文獻連結]
褐藻醣膠在PC-3前列腺癌細胞中的抗癌作用
Boo HJ et al., The anticancer effect of fucoidan in PC-3 prostate cancer cells. Mar Drugs. 2013 Aug 19;11(8):2982-99.[文獻連結]
褐藻醣膠的β1-整合素在細胞凋亡中的重要作用
Yamasaki Y et al., Important role of β1-integrin in fucoidan-induced apoptosis via caspase-8 activation. Biosci Biotechnol Biochem. 2012;76(6):1163-8.[文獻連結]
褐藻醣膠誘導癌細胞凋亡
Chen S, Zhao Y, Zhang Y, Zhang D. Fucoidan induces cancer cell apoptosis by modulating the endoplasmic reticulum stress cascades. PLoS One. 2014 Sep 18;9(9):e108157.[文獻連結]
褐藻糖膠增強樹突細胞成熟與功能，並促進抗原特異性T細胞免疫反應
Jin JO et al., Fucoidan can function as an adjuvant in vivo to enhance dendritic cell maturation and function and promote antigen-specific T cell immune responses. PLoS One. 2014 Jun 9;9(6):e99396.[文獻連結]
褐藻醣膠增強化療劑在乳癌細胞中的抗癌活性
Zhang Z et al., Fucoidan extract enhances the anti-cancer activity of chemotherapeutic agents in MDA-MB-231 and MCF-7 breast cancer cells. Mar Drugs. 2013 Jan 9;11(1):81-98.[文獻連結]
褐藻醣膠與抗癌藥物組合應用於人類癌症小鼠模型
Burney M et al., Evaluation Fucoidan Extracts From Undaria pinnatifida and Fucus vesiculosus in Combination With Anticancer Drugs in Human Cancer Orthotopic Mouse Models. Integr Cancer Ther. 2017:1534735417740631.[文獻連結]
褐藻醣膠用於癌症治療的安全性臨床評估
Mathew L. B, M., Gaikwad, A., Nyshadham P, Nugent, EK., Gonzalez A, Smith JA. Preclinical Evaluation of Safety of Fucoidan Extracts From Undaria pinnatifida and Fucus vesiculosus for Use in Cancer Treatment. Integrative Cancer Therapies. 2016;1-13.[文獻連結]
口服褐藻醣膠對癌症小鼠腫瘤生長與存活時間的影響
Azuma K et al., Effects of oral administration of fucoidan extracted from Cladosiphon okamuranus on tumor growth and survival time in a tumor-bearing mouse model. Mar Drugs. 2012 Oct;10(10):2337-48.[文獻連結]
褐藻醣膠抑制淋巴管新生
Yang Y et al., Fucoidan inhibits lymphangiogenesis by downregulating the expression of VEGFR3 and PROX1 in human lymphatic endothelial cells. Oncotarget. 2016 Jun 21;7(25):38025-38035.[文獻連結]
肺微血管中腫瘤細胞黏附與內皮細胞的交互作用
Gassmann P, Kang ML, Mees ST, Haier J. In vivo tumor cell adhesion in the pulmonary microvasculature is exclusively mediated by tumor cell–endothelial cell interaction. BMC Cancer. 2010 Apr 30;10:177.[文獻連結]
褐藻醣膠對於乳癌患者使用藥物的影響
Tocaciu S et al., The Effect of Undaria pinnatifida Fucoidan on the Pharmacokinetics of Letrozole and Tamoxifen in Patients With Breast Cancer. Integr Cancer Ther. 2018 Mar;17(1):99-105.[文獻連結]
褐藻醣膠降低結直腸癌患者化療的毒性
Ikeguchi M et al., Fucoidan reduces the toxicities of chemotherapy for patients with unresectable advanced or recurrent colorectal cancer. Oncol Lett. 2011 Mar;2(2):319-322.[文獻連結]
褐藻醣膠與藥物併用，改善膀胱癌小鼠因化療引起的骨骼肌萎縮
Chen MC et al., Combined administration of fucoidan ameliorates tumor and chemotherapy-induced skeletal muscle atrophy in bladder cancer-bearing mice. Oncotarget. 2016 Aug 9;7(32):51608-51618.[文獻連結]
保健功能2 褐藻醣膠有效提升免疫力、增加幹細胞數量
補充褐藻醣膠增加對季節性流感疫苗的免疫反應
Negishi H, Mori M, Mori H, Yamori Y. Supplementation of elderly Japanese men and women with fucoidan from seaweed increases immune responses to seasonal influenza vaccination. J Nutr. 2013 Nov;143(11):1794-8.[文獻連結]
海藻萃取營養複合物對免疫調節的影響
Myers SP et al., A combined Phase I and II open-label study on the immunomodulatory effects of seaweed extract nutrient complex. Biologics. 2011;5:45-60.[文獻連結]
褐藻醣膠用於癌症治療的安全性臨床評估
Lata Mathew, BS et al., Preclinical Evaluation of Safety of Fucoidan Extracts From Undaria pinnatifida and Fucus vesiculosus for Use in Cancer Treatment. Integr Cancer Ther. 2017 Dec; 16(4): 572–584.[文獻連結]
局部施用褐藻醣膠改善小鼠特應性皮炎症狀
Yang JH. Topical application of fucoidan improves atopic dermatitis symptoms in NC/Nga mice. Phytother Res. 2012 Dec;26(12):1898-903.[文獻連結]
褐藻醣膠抑制特應性皮炎患者的IgE產生
Iwamoto K. Fucoidan suppresses IgE production in peripheral blood mononuclear cells from patients with atopic dermatitis. Arch Dermatol Res. 2011 Aug;303(6):425-31.[文獻連結]
褐藻醣膠提高猴和小鼠血漿中SDF-1，進而增加幹細胞水平
Sweeney EA et al., Sulfated polysaccharides increase plasma levels of SDF-1 in monkeys and mice: involvement in mobilization of stem/progenitor cells. Blood. 2002 Jan 1;99(1):44-51.[文獻連結]
褐藻醣膠增CD34+細胞CXCR4的表現
Irhimeh MR, Fitton JH, Lowenthal RM. Fucoidan ingestion increases the expression of CXCR4 on human CD34+ cells. Exp Hematol. 2007 Jun;35(6):989-94.[文獻連結]
保健功能3 褐藻醣膠維持腸道健康
褐藻醣膠透過增加乳酸菌數量，調節小鼠腸道微生物群
Shang Q, Shan X, Cai C, Hao J, Li G, Yu G. Dietary fucoidan modulates
the gut microbiota in mice by increasing the abundance of Lactobacillus
and Ruminococcaceae. Food & function. 2016;7(7):3224-32.[文獻連結]
褐藻多醣破壞幽門螺桿菌對胃上皮細胞的粘附作用
Chua EG, Verbrugghe P, Perkins TT, Tay CY. Fucoidans Disrupt Adherence of Helicobacter pylori to AGS Cells In Vitro. Evidence-based complementary and alternative medicine : eCAM. 2015;2015:120981.[文獻連結]
褐藻多醣改善急性結腸炎
Lean QY et al., Fucoidan Extracts Ameliorate Acute Colitis. PLoS One. 2015 Jun 17;10(6):e0128453.[文獻連結]
褐藻糖膠對胃潰瘍的療效
Juffrie M RI, Damayanti W, Djumhana A, Ahmad H. The Efficcay of Fucoidan on Gastric Ulcer. Indonesian Journal of Biotechnology 2006;11(2):908-13.[文獻連結]
褐藻糖膠對阿司匹林所致大鼠胃潰瘍的影響
Choi JI, Raghavendran HR, Sung NY, Kim JH, Chun BS, Ahn DH, et al. Effect of fucoidan on aspirin-induced stomach ulceration in rats. Chem Biol Interact. 2010;183(1):249-54.[文獻連結]
保健功能4 褐藻醣膠解決腸炎、關節炎與全身性炎症
多功能海洋聚合物—褐藻醣膠的療效
Fitton J. Therapies from Fucoidan; Multifunctional Marine Polymers.
Marine Drugs. 2011;9:1731-60[文獻連結]
肺微血管中腫瘤細胞黏附與內皮細胞的交互作用
Gassmann P, Kang ML, Mees ST, Haier J. In vivo tumor cell adhesion in the pulmonary microvasculature is exclusively mediated by tumor cell-endothelial cell interaction. BMC Cancer. 2010;10:177.[文獻連結]
褐藻多醣改善急性結腸炎
Lean QY, Eri RD, Fitton JH, Patel RP, Gueven N. Fucoidan Extracts Ameliorate Acute Colitis. PLoS One. 2015;10(6):e0128453[文獻連結]
海藻提取營養複合物對骨關節炎的影響
Myers SP, O’Connor J, Fitton JH, Brooks L, Rolfe M, Connellan P, et al. A combined phase I and II open label study on the effects of a seaweed extract nutrient complex on osteoarthritis. Biologics. 2010;4:33-44.[文獻連結]
局部施用褐藻醣膠改善小鼠特應性皮炎症狀
Yang JH. Topical Application of Fucoidan Improves Atopic Dermatitis Symptoms in NC/Nga Mice. Phytother Res. 2012.[文獻連結]
保健功能5 褐藻醣膠預防心血管疾病
褐藻醣膠改善血脂水平與動脈粥樣硬化
Park J, Yeom M, Hahm DH.Fucoidan improves serum lipid levels and atherosclerosis through hepatic SREBP-2-mediated regulation. J Pharmacol Sci. 2016 Jun;131(2):84-92.[文獻連結]
褐藻醣膠在周邊缺血的治療作用
Sarlon G et al., Therapeutic effect of fucoidan-stimulated endothelial colony-forming cells in peripheral ischemia. J Thromb Haemost. 2012 Jan;10(1):38-48.[文獻連結]
褐藻醣膠對超重或肥胖成年人胰島素分泌與胰島素阻抗的影響
Hernández-Corona DM, Martínez-Abundis E, González-Ortiz M. Effect of fucoidan administration on insulin secretion and insulin resistance in overweight or obese adults. J Med Food. 2014 Jul;17(7):830-2. [文獻連結]
