左旋精胺酸功效：健身、降血壓、性功能文獻彙整
左旋精胺酸(L-Arginine)是人體中自然存在的精胺酸形態，可促進蛋白質合成、幫助傷口修復、提高免疫機能等，還能幫助運動後肌肉合成、提升運動表現。同時精氨酸也是一氧化氮的前驅物，可以使血管擴張、使血流通暢、降血壓、改善心血管疾病。亦能改善性功能障礙、提升精子活動力、改善男性機能。
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1. 術後補充精胺酸有助傷口癒合、提升免疫力
精胺酸促進蛋白質合成機制
Ruxia Wang et al., L-Arginine Enhances Protein Synthesis by Phosphorylating mTOR (Thr 2446) in a Nitric Oxide-Dependent Manner in C2C12 Cells. Oxid Med Cell Longev. 2018; 2018: 7569127. [文獻連結]
嚴重燒傷後的血漿與骨骼肌胺基酸
Stinnett JD, Alexander JW, Watanabe C, MacMillan BG, Fischer JE, Morris MJ, et al. Plasma and skeletal muscle amino acids following severe burn in patients and experimental animals. Ann Surg 1982;195:75–89. [文獻連結]
左旋精氨酸治療糖尿病患者的足部潰瘍癒合
Arana, V., Paz, Y., González, A., Méndez, V., & Méndez, J. D. (2004). Healing of diabetic foot ulcers in l-arginine-treated patients. Biomedicine & Pharmacotherapy, 58(10), 588–597. [文獻連結]
早期腸內營養補充精氨酸 對嚴重燒傷小鼠腸黏膜免疫功能的影響
Fan, J., Meng, Q., Guo, G., Xie, Y., Li, X., Xiu, Y., Ma, L. (2010). Effects of early enteral nutrition supplemented with arginine on intestinal mucosal immunity in severely burned mice. Clinical Nutrition, 29(1), 124–130. [文獻連結]
2. 健身重訓補充精胺酸、提升運動表現
劉宗翰、張振崗。補充精胺酸對運動表現之影響。大專體育第96期，2008年6月。[文獻連結]
蔡佈曦(2007)。精胺酸補充劑對運動後葡萄糖、游離脂肪酸及抗疲勞的影響。[文獻連結]
胺基酸對肌肉代謝的作用
Komatsu M. Action of amino acids on muscle metabolism. Food Style 21. 6(11):53-6, 2002. [文獻連結]
精氨酸補充提高無氧運動的平均功率輸出
Buford, B. N., & Koch, A. J. (2004). Glycine-arginine-alpha-ketoisocaproic acid improves performance of repeated cycling sprints. Medicine & Science in Sports & Exercise, 36(4), 583-587. [文獻連結]
精胺酸增強高強度無氧運動的肌肉性能
Stevens, B. R., Godfrey, M. D., Kaminski, T. W., & Braith, R. W. (2000). High-intensity dynamic human muscle performance enhanced by a metabolic intervention. Medicine & Science in Sports & Exercise, 32(12), 2102-2108.[文獻連結]
左旋精胺酸可減少運動引起的血漿乳酸和氨的增加
Schaefer, A., Piquard, F., Geny, B., Doutreleau, S., Lampert, E., Mettauer, B., et al. (2002). L-arginine reduces exercise-induced increase in plasma lactate and ammonia. International Journal of Sports Medicine, 23(6), 403-407.[文獻連結]
精胺酸的補充對運動期間血漿氨濃度的影響
Eto, B., Peres, G., & Le Moel, G. (1994). Effects of an ingestedglutamate arginine salt on ammonemia during and after long lasting cycling. Archives Internationales de Physiologie, de Biochimie et de Biophysique, 102(3), 161-162.[文獻連結]
精氨酸對運動誘導的高氨血症的影響
Denis, C., Dormois, D., Linossier, M. T., Eychenne, J. L., Hauseux, P., & Lacour, J. R. (1991). Effect of arginine aspartate on the exercise-induced hyperammoniemia in humans: A two periods cross-over trial. Archives Internationales de Physiologie, de Biochimie et de Biophysique, 99(1), 123-127.[文獻連結]
口服左旋精胺酸改善肺部高血壓患者的血流動力學和運動能力
Nagaya, N., Uematsu, M., Oya, H., Sato, N., Sakamaki, F., Kyotani, S., et al. (2001). Short-term oral administration of L-arginine improves hemodynamics and exercise capacity in patients with precapillary pulmonary hypertension. American Journal of Respiratory & Critical Care Medicine, 163(4), 887-891.[文獻連結]
口服補充左旋精胺酸對穩定型心絞痛患者運動能力的影響
Ceremuzyski, L., Chamiec, T., & Herbaczyska-Cedro, K. (1997). Effect of supplemental oral L-arginine on exercise capacity in patients with stable angina pectoris. American Journal of Cardiology, 80(3), 331-333.[文獻連結]
左旋精胺酸補充劑可增強心力衰竭患者的耐力運動耐受性
Doutreleau, S., Mettauer, B., Piquard, F., Rouyer, O., Schaefer, A., Lonsdorfer, J., et al. (2006). Chronic Larginine supplementation enhances endurance exercise tolerance in heart failure patients. International Journal of Sports Medicine, 27(7), 567-572.[文獻連結]
3. 一氧化氮前驅物：降血壓、改善心血管疾病
內皮功能障礙
Endemann, D. H., & Schiffrin, E. L. (2004). Endothelial dysfunction. Journal of the American Society of Nephrology, 15(8), 1983-1992. [文獻連結]
精氨酸營養和心血管功能
Wu G1, Meininger CJ. Arginine nutrition and cardiovascular function. J Nutr. 2000 Nov;130(11):2626-9. [文獻連結]
口服左旋精胺酸改善內皮依賴性擴張，減少冠狀動脈疾病單核細胞與內皮細胞的粘附
Adams, M. R. et al., Oral l-arginine improves endothelium-dependent dilatation and reduces monocyte adhesion to endothelial cells in young men with coronary artery disease. Atherosclerosis, 129(2), 261–269. [文獻連結]
醫療食品應用於慢性穩定性心絞痛飲食管理的隨機試驗
Maxwell, A. J. et al., Randomized trial of a medical food for the dietary management of chronic, stable angina. Journal of the American College of Cardiology, 39(1), 37-45. [文獻連結]
左旋精胺酸補充對周邊動脈疾病功能的初步研究
Oka, R. K., Szuba, A., Giacomini, J. C., & Cooke, J. P. (2005). A pilot study of L-arginine supplementation on functional capacity in peripheral arterial disease. Vascular Medicine, 10(4), 265-274.[文獻連結]
口服左旋精胺酸改善肺部高血壓患者的血流動力學和運動能力
Nagaya, N., Uematsu, M., Oya, H., Sato, N., Sakamaki, F., Kyotani, S., et al. (2001). Short-term oral administration of L-arginine improves hemodynamics and exercise capacity in patients with precapillary pulmonary hypertension. American Journal of Respiratory & Critical Care Medicine, 163(4), 887-891.[文獻連結]
口服補充左旋精胺酸對穩定型心絞痛患者運動能力的影響
Ceremuzyski, L., Chamiec, T., & Herbaczyska-Cedro, K. (1997). Effect of supplemental oral L-arginine on exercise capacity in patients with stable angina pectoris. American Journal of Cardiology, 80(3), 331-333.[文獻連結]
左旋精胺酸補充劑可增強心力衰竭患者的耐力運動耐受性
Doutreleau, S., Mettauer, B., Piquard, F., Rouyer, O., Schaefer, A., Lonsdorfer, J., et al. (2006). Chronic Larginine supplementation enhances endurance exercise tolerance in heart failure patients. International Journal of Sports Medicine, 27(7), 567-572.[文獻連結]
運動訓練和口服左旋精胺酸補充劑對心衰竭患者的影響
Hambrecht, R., Hilbrich, L., Erbs, S., Gielen, S., Fiehn, E., Schoene, N., et al. (2000). Correction of endothelial dysfunction in chronic heart failure: Additional effects of exercise training and oral L-arginine supplementation. Journal of the American College of Cardiology, 35(3), 706-713.[文獻連結]
口服左旋精胺酸可改善70歲以上老人的內皮功能
Bode-Boger, S. M., Muke, J., Surdacki, A., Brabant, G., Boger, R. H., & Frolich, J. C. (2003). Oral L-arginine improves endothelial function in healthy individuals older than 70 years. Vascular Medicine, 8(2), 77-81.[文獻連結]
口服左旋精胺酸改善心臟衰竭患者前臂動脈血管舒張
Prior, D. L., Jennings, G. L. R., & Chin-Dusting, J. P. (2000). Transient improvement of acetylcholine responses after short-term oral L-arginine in forearms of human heart failure. Journal of Cardiovascular Pharmacology, 36(1), 31-37.[文獻連結]
左旋精胺酸改善高膽固醇血症的內皮功能障礙
Kawano, H., Motoyama, T., Hirai, N., Kugiyama, K., Yasue, H., & Ogawa, H. (2002). Endothelial dysfunction in hypercholesterolemia is improved by L-arginine administration: Possible role of oxidative stress. Atherosclerosis, 161(2), 375-380. [文獻連結]
口服左旋精胺酸改善高膽固醇血症年輕成人的內皮依賴性擴張
Clarkson, P., Adams, M. R., Powe, A. J., Donald, A. E., Mccredie, R., Robinson, J., et al. (1996). Oral L-arginine improves endothelium-dependent dilation in hypercholesterolemic young adults. Journal of Clinical Investigation, 97(8), 1989-1994.[文獻連結]
口服左旋精胺酸改善原發性高血壓患者的內皮功能障礙
Lekakis, J. P., Papathanassiou, S., Papaioannou, T. G., Papamichael, C. M., Zakopoulos, N., Kotsis, V., et al. (2002). Oral L-arginine improves endothelial dysfunction in patients with essential hypertension. International Journal of Cardiology, 86(2-3), 317-323.[文獻連結]
4. 精胺酸改善陰莖勃起、性功能障礙、提升精子活動力
勃起功能障礙患者的左旋精氨酸和瓜氨酸水平
Barassi A et al., Levels of l-arginine and l-citrulline in patients with erectile dysfunction of different etiology. Andrology. 2017 Mar;5(2):256-261. doi: 10.1111/andr.12293. Epub 2017 Feb 8. [文獻連結]
口服大劑量左旋精胺酸對勃起功能障礙男性的影響
Chen Wollman Chernichovsky Iaina Sofer Matzkin. Effect of oral administration of high‐dose nitric oxide donor l‐arginine in men with organic erectile dysfunction: results of a double‐blind, randomized, placebo‐controlled study. [文獻連結]
精胺酸與精子粒線粒體功能和運動
Otasevic V, Korac A, Vucetic M, et al. Is Manganese (II) Pentaazamacrocyclic Superoxide Dismutase Mimic Beneficial for Human Sperm Mitochondria Function and Motility? Antioxidants & Redox Signaling. 2013;18(2):170-178. [文獻連結]
