維生素B群功效有哪些？4大功能相關研究文獻彙整
酵母維生素B群的臨床功效已經眾多文獻證實：
以下根據維生素B群在各方面的功效與保健功能，進行文獻統整：
保健功能一 維生素B群與腦神經健康
廣告贊助☒
硫胺(維生素B1)營養狀態與抑鬱症狀呈負相關
G. Zhang, H. Ding, H. Chen, X. Ye, H. Li, X. Lin, et al., Thiamine nutritional status and depressive symptoms are inversely associated among older Chinese adults, J. Nutr. 143 (2013) 53–58.
硫胺素(維生素B1)補充對健康的好處
L.J. Smidt, F.M. Cremin, L.E. Grivetti, A.J. Clifford, Influence of thiamin supplementation on the health and general well-being of an elderly Irish population with marginal thiamin deficiency, J. Gerontol. 46 (1991) M16–M22.
硫胺素(維生素B1)改善重度抑鬱症患者的標準治療
A. Ghaleiha, H. Davari, L. Jahangard, M. Haghighi, M. Ahmadpanah, M.A. Seifrabie, et al., Adjuvant thiamine improved standard treatment in patients with major depressive disorder: results from a randomized, double-blind, and placebo-controlled clinical trial, Eur. Arch. Psychiatry Clin. Neurosci. 266 (2016) 695–702.
低劑量菸鹼酸(維生素B3)補充劑可調節GPR109A，改善帕金森氏症
Wakade C., Chong R., Bradley E., Morgan J.C. Low-dose niacin supplementation modulates GPR109A, niacin index and ameliorates parkinson’s disease symptoms without side effects. Clin. Case Rep. 2015;3:635–637. doi: 10.1002/ccr3.232.
老年人攝取葉酸、維生素B6和B12，與罹患抑鬱症的風險研究
Gougeon L et al., Intakes of folate, vitamin B6 and B12 and risk of depression in community-dwelling older adults: the Quebec Longitudinal Study on Nutrition and Aging.Eur J Clin Nutr. 2016 Mar;70(3):380-5.
中年芬蘭男性的膳食葉酸攝取與抑鬱症的關聯
T. Tolmunen, S. Voutilainen, J. Hintikka, T. Rissanen, A. Tanskanen, H. Viinamaki, et al., Dietary folate and depressive symptoms are associated in middle-aged Finnish men, J. Nutr. 133 (2003) 3233–3236.
維生素B12水平與抑鬱型憂鬱症的關聯
J. Seppala, H. Koponen, H. Kautiainen, J.G. Eriksson, O. Kampman, J. Leiviska, et al., Association between vitamin b12 levels and melancholic depressive symptoms: a Finnish population-based study, BMC Psychiatry 13 (2013) 145.
補充維生素B12可治療重度抑鬱症
E.U. Syed, M. Wasay, S. Awan, Vitamin B12 supplementation in treating major depressive disorder: a randomized controlled trial, Open Neurol. J. 7 (2013) 44–48.
維生素B透過影響免疫/細胞激素，進一步影響抑鬱症
Kathleen Mikkelsen et al., The effects of vitamin B on the immune/cytokine network and their involvement in depression. Maturitas 96 (2017) 58–71
保健功能二 維他命B群與心血管健康
血漿同半胱氨酸可做為血管疾病的危險因素評估。增加葉酸攝取的可能好處
Boushey CJ et al., A quantitative assessment of plasma homocysteine as a risk factor for vascular disease. Probable benefits of increasing folic acid intakes. JAMA. 1995 Oct 4;274(13):1049-57.
同半胱氨酸和冠狀動脈疾病：與維生素B12、B6、磷酸吡哆醛和葉酸的關係
Dalery K et al., Homocysteine and coronary artery disease in French Canadian subjects: relation with vitamins B12, B6, pyridoxal phosphate, and folate. Am J Cardiol. 1995 Jun 1;75(16):1107-11.
冠心病發病率與血清總同半胱氨酸、相關遺傳多樣性、維生素B群的關聯
Folsom AR et al., Prospective study of coronary heart disease incidence in relation to fasting total homocysteine, related genetic polymorphisms, and B vitamins: the Atherosclerosis Risk in Communities (ARIC) study. Circulation. 1998 Jul 21;98(3):204-10.
維生素B12和B6對心腦血管病發生風險的影響
蘭欣,黨少農,趙亞玲,顏虹,嚴惠.葉酸、維生素B12和B6聯合使用對心腦血管病發生風險影響隨機對照試驗的Meta分析[J].中華流行病學雜志,2016,37(7):1028-1034.
不同劑量的葉酸和維生素B12治療深靜脈血栓和高同半胱氨酸血症
Shu XJ et al., Different doses of folic acid and vitamin B12 to treat rabbits with deep venous thrombosis and hyperhomocysteinemia. Exp Ther Med. 2018 Mar;15(3):2874-2878.
保健功能三 維生素B群與貧血
大鼠核黃素缺乏症：對鐵利用和損失的影響
Powers HJ et al., Riboflavin deficiency in the rat: effects on iron utilization and loss. Br J Nutr. 1991 May;65(3):487-96.
鐵與核黃素在改善男性和兒童小球性貧血的效果
Powers HJ et al., The relative effectiveness of iron and iron with riboflavin in correcting a microcytic anaemia in men and children in rural Gambia. Hum Nutr Clin Nutr. 1983 Dec;37(6):413-25.
中國人核黃素攝入量不足與貧血風險
Zumin Shi et al., Inadequate Riboflavin Intake and Anemia Risk in a Chinese Population: Five-Year Follow Up of the Jiangsu Nutrition Study. PLoS One. 2014; 9(2): e88862.
口服高劑量維生素B12治療惡性貧血
Berlin H, Berlin R, Brante G. Oral treatment of pernicious anemia with high doses of vitamin B12 without intrinsic factor. Acta Med Scand. 1968 Oct;184(4):247-58.
惡性貧血患者對維生素B12的吸收情況
C. C. Ungley Absorption of Vitamin B12 in Pernicious Anaemia: I. Oral Administration Without a Source of Intrinsic Factor. Br Med J. 1950 Oct 21; 2(4685): 905–908.
口服鈷胺素(維生素B12)有效治療鈷胺素缺乏症
Antoinette M et al., Effective Treatment of Cobalamin Deficiency With Oral Cobalamin. Blood 1998 92:1191-11980.
保健功能四 維他命B群預防白內障、青光眼
白內障患者的硫胺素(維生素B1)、核黃素(維生素B2)和吡哆醇(維生素B6)營養狀況
Bhat, K. S. (1987). Nutritional states of thiamine, riboflavin, and pyridoxine in cataract patients. Nutr. Rep. Int. 36:685–692.
穀胱甘肽還原酶在不同物種和人類白內障晶狀體的分佈
Srivastava, S. K., Villacorte, D. and Arya, D.V. (1973). Letter: distribution of glutathione reductase in lens epithelium, cortex and nucleus in various species and in human cataractous lenses. Exp. Eye Res. 16:319–521
白內障研究。兩項營養干預試驗
Sperduto, R. D., Hu, T. S. and Milton, R. C. (1993). The Linxian cataract studies. Two nutrition intervention trials. Arch. Opthalmol. 111:1246–1253.
維生素B3調節線粒體易損性，並預防老年小鼠的青光眼
Pete A Williams et al., Vitamin B3 modulates mitochondrial vulnerability and prevents glaucoma in aged mice. Science. 2017 Feb 17; 355(6326): 756–760.
口服彌可保(活性維生素B12)前後青光眼視野缺損的比較
艾風榮,李靜貞,李瑩,等. 口服彌可保前後青光眼視野缺損的比較[J]. 眼科新進展,2001,(6):430-432.
比較青光眼患者口服彌可保(活性維生素B12)前後視野變化及護理幹預
王芳. 比較青光眼患者口服彌可保前後視野變化及護理幹預. 中國現代藥物應用,2016,(22):164-165.
長效甲基鈷胺素(維生素B12)治療對正常眼壓性青光的眼視野缺損影響
Effects of long-term methylcobalamin treatment on the progression of visual field defects in normal-tension glaucoma. Current Therapeutic Research. 2000 July;61(7):443-451.
提升維他命B群利用率的秘訣
大多數維生素和礦物質補充劑都是用無機營養素製成的。在這種形式下，這些分子在人體內的吸收不佳，生物利用度低。酵母可以作為生物載體，提升營養素含量的同時，酵母菌的轉換可以使營養素在生物體內的利用率顯著提升，使營養素能更充分地被人體吸收利用。
