薑黃四大功效與好處—薑黃素文獻研究彙整

薑黃素文獻研究彙整 – 薑黃四大功效與好處

美國Longvida的SLCP薑黃素,具抗氧化、抗發炎和清除Aβ斑塊的神經保護功效,有助於改善阿茲海默症,從薑黃萃取出的薑黃素,抗氧化力比維生素E高10倍,且有強大的抗發炎功能,為強效的保肝劑,臨床證實有護肝的功效,可降低肝指數,並改善骨關節炎、類風濕性關節炎。 薑黃功效多,此篇整理薑黃素四大好處,分別整理了文獻:

一、薑黃素預防老人失智症、阿茲海默症→看更多

二、薑黃素抗氧化、抗發炎→看更多

三、薑黃素護肝、預防肝炎、肝癌、肝病,降低肝指數→看更多

四、薑黃素改善退化性關節炎、類風濕性關節炎→看更多

 

 

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以下是文獻彙整,薑黃功效文章請按上面的「看更多」

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服用Longvida薑黃素,可使紅血球與血漿中的薑黃素水平顯著增加(反映組織吸收)。
Koronyo Y et al., Retinal amyloid pathology and proof-of-concept imaging trial in Alzheimer’s disease. JCI Insight. 2017 Aug 17;2(16). [文獻連結]

經過SLCP技術處理的微粒薑黃素,生物利用度較一般95%薑黃素類提取物高達65倍。
Gota VS et al., Safety and pharmacokinetics of a solid lipid curcumin particle formulation in osteosarcoma patients and healthy volunteers. J Agric Food Chem. 2010 Feb 24;58(4):2095-9. [文獻連結]

薑黃怎麼吃才有效?65倍高吸收率薑黃品牌推薦

一、薑黃素預防失智症(阿茲海默症)→看更多

薑黃素可調節先天免疫系統的缺陷,改善50%阿茲海默症患者對β-澱粉樣蛋白斑塊(Aβ)的清除效率,減少異常斑塊堆積對大腦造成的影響。
Zhang L, Fiala M, Cashman J, Sayre J, Espinosa A, Mahanian M, et al. Curcuminoids enhance amyloid -beta uptake by macrophages of Alzheimer’s disease patients. J Alzheimers Dis. 2006;10:1–7. [文獻連結]

薑黃素有助於Tau蛋白的清除,即使在在神經纏結形成後,也能有助於改善神經突觸缺陷。
Ma QL et al., Curcumin Suppresses Soluble Tau Dimers and Corrects Molecular Chaperone, Synaptic, and Behavioral Deficits in Aged Human Tau Transgenic Mice. J Biol Chem. 2013 Feb 8;288(6):4056-65. [文獻連結]

每日補充100mg薑黃素,12週後可減少失智症的嚴重心理症狀,如妄想、幻覺、冷漠、激動、焦慮、煩躁和抑鬱等。
Hishikawa N et al., Effects of turmeric on Alzheimer’s disease with behavioral and psychological symptoms of dementia. Ayu. 2012 Oct;33(4):499-504. [文獻連結]

SLCP技術處理的薑黃素,在大腦有更高的滲透性,使其能夠有力的抑制Aβ斑塊,並具有更有效的抗發炎和神經保護作用,因此可以為阿茲海默症提供更有效的治療。
Maiti P, Paladugu, Dunbar GL. Solid lipid curcumin particles provide greater anti-amyloid, anti-inflammatory and neuroprotective effects than curcumin in the 5xFAD mouse model of Alzheimer’s disease. BMC Neurosci. 2018 Feb 23;19(1):7. [文獻連結]

每天400mg的Longvida®薑黃素(含80mg薑黃素),可顯著改善持續注意力和工作記憶的表現。並顯著降低總膽固醇、低密度脂蛋白(LDL)。
Cox KH, Pipingas A, Scholey AB. Investigation of the effects of solid lipid curcumin on cognition and mood in a healthy older population. J Psychopharmacol. 2015 May;29(5):642-51. [文獻連結]

每天400mg的Longvida®薑黃素(含80mg薑黃素),4週後可降低血漿β-澱粉樣蛋白的濃度,對於抗氧化、抗發炎、提升免疫、抗動脈粥狀硬化、降血壓、降低肝損傷等具有各種潛在的健康促進作用。
DiSilvestro RA, Joseph E, Zhao S, Bomser J. Diverse effects of a low dose supplement of lipidated curcumin in healthy middle aged people. Nutr J. 2012 Sep 26;11:79. [文獻連結]

薑黃素可有效地抑制星形膠質細胞活化、減少促炎性細胞因子的釋放,並阻斷神經退化的進展,包括tau蛋白和澱粉樣蛋白的積聚,以及神經認知障礙。
Sundaram JR et al., Curcumin Ameliorates Neuroinflammation, Neurodegeneration, and Memory Deficits in p25 Transgenic Mouse Model that Bears Hallmarks of Alzheimer’s Disease. J Alzheimers Dis. 2017;60(4):1429-1442. [文獻連結]

薑黃功效

二、薑黃素抗氧化、抗發炎→看更多

SLCP薑黃素可顯著降低促進發炎細胞因子(前列腺素PGE-2)的濃度,且薑黃素濃度愈高,效果愈顯著。
Nahar PP, Slitt AL, Seeram NP. Anti-Inflammatory Effects of Novel Standardized Solid Lipid Curcumin Formulations. J Med Food. 2015 Jul;18(7):786-92. [文獻連結]

每天400mg的Longvida®薑黃素,可降低發炎細胞因子TNF-α、IL-6、IL-8、IL-10,緩解肌肉損傷造成的發炎反應。
McFarlin BK et al. Reduced inflammatory and muscle damage biomarkers following oral supplementation with bioavailable curcumin. BBA Clin. 2016 Feb 18;5:72-8. [文獻連結]

薑黃素可抑制促炎細胞因子NF-κB,從而抑制炎症級聯反應。
Nanji, A.A., Jokelainen, K., Tipoe, G.L., Rahemtulla, A., Thomas, P., Dannenberg, A.J., 2003. Curcumin prevents alcohol-induced liver disease in rats by inhibiting the expression of NF-κB-dependent genes. Am. J. Physiol-Gastrointestinal Liver Physiol., 284, G321G327. [文獻連結]

薑黃素可上調Nrf2基因,使我們體內的抗氧化酵素GSH、GSH-Px、SOD活性升高,三者協同作用來清除自由基,防止自由基對細胞、組織、器官的傷害。
Oppenheimer, A., 1937. Turmeric (curcumin) in biliary diseases. Lancet 229, 619-621. [文獻連結]

薑黃素的抗氧化力比維生素E高10倍。
Jagetia, G.C., Rajanikant, G.K., 2015. Curcumin stimulates the antioxidant mechanisms in mouse skin exposed to fractionated γ-irradiation. Antioxidants 4, 25-41. [文獻連結]

薑黃素可以防止細胞結構損傷、降低脂質過氧化,防止穀胱甘肽耗竭,同時通過上調Keap1-Nrf2-ARE途徑,提高抗氧化物質SOD、CAT、GPx、GR、GST和NQO1的活性;薑黃素還降低NF-κB的活化和促炎細胞因子的表達。
García-Niño, W.R., Pedraza-Chaverrí, J., 2014. Protective effect of curcumin against heavy metals-induced liver damage. Food Chem. Toxicol., 69, 182-201. [文獻連結]

三、薑黃素護肝、預防肝炎、肝癌、肝病,降低肝指數→看更多

薑黃素可透過抗氧化、抗發炎兩大機制,保護肝臟組織不受傷害,預防各種肝臟疾病。
Khan H, Ullah H, Nabavi SM. Mechanistic insights of hepatoprotective effects of curcumin: Therapeutic updates and future prospects. Food Chem Toxicol. 2019 Feb;124:182-191. [文獻連結]

薑黃素可降低總膽紅素、ALT(GPT)、AST(GOT)、ALP、LDH、GGT等活性,並提高血清蛋白,對於肝病造成的膽汁淤積(黃疸)、肝纖維化和肝癌,有積極的治療效果。
Shishodia, S., Sethi, G., Aggarwal, B.B., 2005. Curcumin: getting back to the roots. Ann New York Acad. Sci., 1056, 206-217. [文獻連結]

薑黃素(Curcumin)可透過下調PGC-1α,抑制B肝病毒的基因表達,並抑制病毒增生。
Rechtman MM et al., Curcumin inhibits hepatitis B virus via down-regulation of the metabolic coactivator PGC-1alpha. FEBS Lett. 2010 Jun 3;584(11):2485-90. [文獻連結]

薑黃素可抑制HBV表面抗原(HBsAg)和e抗原(HBeAg)的表達水平,並破壞HBV cccDNA的穩定狀態,有效抑制B型肝炎病毒的mRNA轉錄和蛋白質表達,減少病毒DNA複製。
Wei ZQ et al., Curcumin inhibits hepatitis B virus infection by down-regulating cccDNA-bound histone acetylation. World J Gastroenterol. 2017 Sep 14;23(34):6252-6260. [文獻連結]

薑黃素的抗氧化能力,能保護免受APAP誘導的肝毒性,可降低肝臟氧化壓力指標ALT(GPT)、AST(GOT)、ALP和丙二醛(MDA)
Girish, C., Koner, B.C., Jayanthi, S., Ramachandra Rao, K., Rajesh, B., Pradhan, S.C., 2009. Hepatoprotective activity of picroliv, curcumin and ellagic acid compared to silymarin on paracetamol induced liver toxicity in mice. Fund. Clin. Pharmacol., 23, 735-745.[文獻連結]

薑黃素增加抗氧化物質GSH,並降低引發炎症的細胞因子IL-1β、TNF-α和IL-8,從而防止肝損傷。
Soliman, M.M., Nassan, M.A., Ismail, T.A., 2014. Immunohistochemical and molecular study on the protective effect of curcumin against hepatic toxicity induced by paracetamol in Wistar rats. BMC Complement. Alter. Med., 14, 457. [文獻連結]

薑黃素通過誘導血紅素加氧酶HO-1的表達,來保護肝臟免受酒精損害,並降低乙醇誘導的LDH、AST、MDA的血漿濃度,同時增加GSH的濃度,發揮抗氧化作用,避免酒精毒性造成的氧化壓力傷害。
Bao, W., Li, K., Rong, S., Yao, P., Hao, L., Ying, C., Zhang, X., Nussler, A., Liu, L., 2010. Curcumin alleviates ethanol-induced hepatocytes oxidative damage involving heme oxygenase-1 induction. J. Ethnopharmacol., 128, 549-553. [文獻連結]

薑黃素可以與鉛結合形成複合物,保護免受鉛的神經毒性和腎毒性傷害,防止重金屬誘導的肝毒性。
Gupta, V.K., Singh, S., Agrawal, A., Siddiqi, N.J., Sharma, B., 2015. Phytochemicals mediated remediation of neurotoxicity induced by heavy metals. Biochem. Res. Int., 2015. [文獻連結]

薑黃脂肪肝

四、薑黃素改善骨關節炎、類風濕性關節炎→看更多

40名患有輕度至中度骨關節炎的受試者,接受薑黃素(1500 mg/天,分三次服用),六週後疼痛指數和身體功能評分皆有顯著改善,並無明顯不良反應。
Panahi Y et al., Curcuminoid treatment for knee osteoarthritis: a randomized double-blind placebo-controlled trial. Phytother Res. 2014 Nov;28(11):1625-31. [文獻連結]

針對類風溼性關節炎的患者,比較薑黃素與非類固醇止痛藥(NSAIDs)雙氯芬酸(diclofenac)的效果與安全性,薑黃素組總體DAS和ACR評分的改善百分比最高,且明顯優於雙氯芬酸鈉組,相較於藥物無任何不良副作用,安全性高。
Chandran B, Goel A. A randomized, pilot study to assess the efficacy and safety of curcumin in patients with active rheumatoid arthritis. Phytother Res. 2012 Nov;26(11):1719-25. [文獻連結]

薑黃提取物(劑量通常為1000mg /天),可以減輕關節炎疼痛、發炎的症狀,且改善效果和市售非類固醇止痛藥(NSAIDs)如布洛芬(ibuprofen)、雙氯芬酸(diclofenac),緩解疼痛的效果相當。
Daily JW, Yang M, Park S. Efficacy of Turmeric Extracts and Curcumin for Alleviating the Symptoms of Joint Arthritis: A Systematic Review and Meta-Analysis of Randomized Clinical Trials. J Med Food. 2016 Aug;19(8):717-29. [文獻連結]